As we advanced earlier , to go to Holbox you have to leave from Chiquilá. And, the most practical way to get to Chiquilá from Cancun is by bus. The buses (or, as they are called in Mexico, “trucks”) are from the ADO company and leave from the ADO bus station, located in downtown Cancun.
There is only one bus that goes directly from Cancun to Chiquilá. Being direct, does not stop at any time of the tour.
If you don't take the direct bus, you can still take a bus that stops in different towns. It is also the company ADO, and leaves the same terminal. When stopping in these intermediate villages, it takes longer to arrive and, when many people get on and off the way, many will stop.
Try to buy your tickets in advance since, if the bus quota is completed, you will have to wait until the next day to travel to Chiquilá. We also recommend taking the direct bus which, although it is a bit more expensive, will save you time and travel more comfortable.